ACT for FOP

ACT for FOP

About the ACT for FOP Grant Program

The IFOPA offers the ACT (Accelerating Cures and Treatments) for the FOP grant program to help enable the research and development of safe and transformative therapies for fibrodysplasia ossificans progressiva (FOP). The research grant program provides, through a competitive application process, funding to scientists conducting research on FOP.


Research Focus

Research grants should focus on the discovery and advancement of therapeutic approaches to FOP, including:

  • Potential new therapies that either provide a novel approach to treating FOP or have convincing animal data to warrant further research;
  • Preclinical research that investigates a drug’s effectiveness on post-resection of heterotopic bone;
  • Research that assesses novel imaging techniques that have the near term potential to be used as a biomarker or endpoint in clinical trials; and
  • Research that further elucidates the mechanisms for FOP muscle regeneration as well as tendon and ligament repair.

Grant requests to test either combination treatments or repurposed drugs should be directed to the IFOPA’s Pre-Clinical Drug Testing Program. For further information on the IFOPA Pre-Clinical Drug Testing Program, or to discuss or review your grant submission to the ACT for FOP Grant Program, please contact us at grants@ifopa.org.

Proposals involving meaningful collaboration among investigators with complementary capabilities are encouraged. Awards can be split among the investigators’ institutions as needed. Grant funds cannot be used for indirect or overhead costs.


Mechanism of Support

The ACT for FOP Grant Program awards one-year research grants to selected recipients. The IFOPA anticipates awarding multiple grants for the 2020 ACT for FOP Grant Program. Researchers may be considered for a second year of funding based on their progress and milestones achieved in the first year and the availability of continued funding.

Applications that are scored favorably but not funded during the initial awards cycle may be funded as additional money becomes available.

The Scientific Advisory Board does not provide a written evaluation back to the applicants.

For more information about the ACT for FOP grant program, including information on the evaluation process and criteria, please see the Grant Program Application Guidelines.


Eligibility

FOP researchers with a doctoral degree (MD, Ph.D. or equivalent) at any stage of their career in any country are eligible to apply. Applications must be in English.


Proposal Evaluation Process

All grant applications are blinded with respect to investigator and institution identity for review by the Scientific Advisory Board. The Scientific Advisory Board then rates proposals according to the defined criteria for evaluation and assesses the overall likelihood for the project to make a significant advancement towards for FOP. Once proposals have been fully evaluated on all metrics except for investigator capabilities, the identity of the applicants is unblinded to allow for discussion of investigator and institutional capabilities. The Scientific Advisory Board then develops a recommendation to the IFOPA for funding recipients and amounts.

The IFOPA Research Committee is convened to review the recommendations of the Scientific Advisory Board and to develop a proposal for approval by the IFOPA Board of Directors.

Applications that are scored favorably but not funded during the initial awards cycle may be funded as additional money becomes available.

The Scientific Advisory Board does not provide a written evaluation back to the applicants.


Confidentiality

The submission of proposals and the identity of applicants is sensitive information that is treated by the IFOPA and the Scientific Advisory Board as confidential. Winning applications will be announced publicly, but other applications will remain confidential.

 
2020 Application Schedule

March 13, 2020 Announcement of program
June 3, 2020 Deadline for proposals
October 5, 2020 Grant applicants notified
December 1, 2020 Funding available


How to Apply

Please consult and follow these application materials and instructions:

Grant Program Application Guidelines

Completed applications should be submitted in a single PDF file to grants@ifopa.org.


Scientific Advisory Board

Applications are reviewed by a Scientific Advisory Board that is free of conflict of interest and has relevant and appropriate expertise related to FOP to evaluate proposals.

The IFOPA Scientific Advisory Board includes:
Vicki Rosen, Ph.D., Chair
Department of Developmental Biology
Harvard School of Dental Medicine
https://hsdm.harvard.edu/people/vicki-rosen
Karen Lyons, Ph.D.
Department of Molecular, Cell and Developmental Biology
UCLA/Orthopaedic Hospital Department of Orthopaedic Surgery
https://www.mcdb.ucla.edu/Research/Lyons/Lab_members.html
Michael Whyte, MD
Division of Bone & Mineral Diseases
Washington University School of Medicine
http://wuphysicians.wustl.edu/physician2.aspx?PhysNum=595
Michael Zasloff, MD, Ph.D.
Department of Surgery
Georgetown University Medical Center
http://explore.georgetown.edu/people/maz5/

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