ACT for FOP Grants

About the ACT for FOP Grant Program

The IFOPA offers the ACT (Accelerating Cures and Treatments) for FOP grant program to help enable the research and development of safe and transformative therapies for fibrodysplasia ossificans progressiva (FOP). The research grant program provides, through a competitive application process, funding to scientists conducting research on FOP.

Research Focus

Research grants should focus on the discovery and advancement of therapeutic approaches to FOP, including:

  • Potential new therapies that either provide a novel approach to treating FOP or have convincing animal data to warrant further research;
  • Combination treatments that may provide better efficacy, allow for more persistent treatment, or to allow treatment for the pediatric population;
  • Repurposed drugs that already have a known safety profile and could be a treatment option;
  • Preclinical research that investigates a drug’s effectiveness post-resection of heterotopic bone;
  • Research that assesses novel imaging techniques that have the near-term potential to be used as a biomarker or endpoint in clinical trials;
  • Research that further elucidates the mechanisms for FOP muscle regeneration as well as tendon and ligament repair.

Proposals involving meaningful collaboration among investigators with complementary capabilities are encouraged. Awards can be split among the investigators’ institutions as needed. Grant funds cannot be used for indirect or overhead costs.

Mechanism of Support

The program awards research grants for a maximum of $100,000 for one year. In 2018 and 2017, the IFOPA has awarded $200,000 and $245,000, respectively, to grant recipients. The IFOPA anticipates awarding multiple grants for the 2019 ACT for FOP grant program. Researchers may be considered for a second year of funding based on their progress and milestones achieved in the first year and the availability of continued funding.

Applications that are scored favorably but not funded during the initial awards cycle may be funded as additional money becomes available.

The Scientific Advisory Board does not provide a written evaluation back to the applicants.

For more information about the ACT for FOP grant program, including information on the evaluation process and criteria, please see the Grant Program Application Guidelines.


FOP researchers with a doctoral degree (MD, PhD or equivalent) at any stage of their career in any country are eligible to apply. Applications must be in English.

Proposal Evaluation Process

All grant applications are blinded with respect to investigator and institution identity for review by the Scientific Advisory Board. The Scientific Advisory Board then rates proposals according to the defined criteria for evaluation and assesses the overall likelihood for the project to make a significant advancement towards for FOP. Once proposals have been fully evaluated on all metrics except for investigator capabilities, the identity of the applicants is unblinded to allow for discussion of investigator and institutional capabilities. The Scientific Advisory Board then develops a recommendation to the IFOPA for funding recipients and amounts.

The IFOPA Research Committee is convened to review the recommendations of the Scientific Advisory Board and to develop a proposal for approval by the IFOPA’s Board of Directors.

Applications that are scored favorably but not funded during the initial awards cycle may be funded as additional money becomes available.

The Scientific Advisory Board does not provide a written evaluation back to the applicants. 


The submission of proposals and the identity of applicants is sensitive information that is treated by the IFOPA and the Scientific Advisory Board as confidential. Winning applications will be announced publicly, but other applications will remain confidential.

2019 Application Schedule

March 21, 2019 Announcement of program
June 4, 2019 Deadline for proposals
October 15, 2019 Grant applicants notified
December 1, 2019 Funding available

How to Apply

Please consult and follow these application materials and instructions:

2019 ACT for FOP Grant Program Application Guidelines

ACT for FOP Grant Program Terms and Conditions

Complete applications should be submitted in a single PDF file to

ACT for FOP Scientific Advisory Board

ACT for FOP applications is reviewed by a Scientific Advisory Board that is free of conflict of interest and has relevant and appropriate expertise related to FOP to evaluate proposals.

The IFOPA Scientific Advisory Board includes:

Vicki Rosen, PhD, Chair
Department of Developmental Biology
Harvard School of Dental Medicine

Karen Lyons, PhD
Department of Molecular, Cell and Developmental Biology
UCLA/ Orthopaedic Hospital Department of Orthopaedic Surgery

Ernestina Schipani, MD, PhD
Department of Orthopaedic Surgery
University of Michigan  

Michael Whyte, MD
Division of Bone & Mineral Diseases
Washington University School of Medicine

Paul Yu, MD, PhD (Reviewer only for the Million Dollar Bike Ride Program)
Department of Cardiovascular Medicine
Brigham and Women's Hospital

Michael Zasloff, MD, PhD
Department of Surgery
Georgetown University Medical Center



Make a Difference

Donate Connect Fundraise

Already a Member? Sign In

Sign Up for FOP Connection, Our Monthly eNewsletter