Funding Opportunities

IFOPA FOP Competitive Research Grants Program

About the Competitive Research Grant Program

The IFOPA offers the FOP Competitive Research Grant (CRG) Program to help accelerate development of safe and transformative therapies for the disease. The research grant program provides, through a competitive application process, funding to scientists conducting research on fibrodysplasia ossificans progressiva (FOP). The CRG Program was started by the IFOPA in 2015 and in the last three years has awarded more than $480,000 to fund 10 grants. 

Research Focus

Research grants should focus on discovery and advancement of new therapeutic approaches to FOP with preference towards approaches likely to have near-term clinical or translational relevance.

2017 Grants

H-SAADDs: Hypoxia-Selective ALK2 Allosteric Destabilizers & Degraders for FOP Prophylaxis

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Principal Investigator: Jay Groppe, Ph.D
Institution: Texas A&M University College of Dentistry, United States
Award Amount: $69,832
Funded by Joshua's Future of Promises

Project Description: Dr. Jay Groppe has developed a very new approach to targeting the faulty receptor in FOP. Instead of turning the receptor off, Dr. Groppe has designed a compound that will degrade and eliminate the mutant receptor. One very unique characteristic of this compound is that it is more active during periods of hypoxia (i.e. lack of tissue oxygen), which is found in FOP lesions. Consequently, this drug could be taken chronically, but it would only “turn on” when there is a flare or during bone formation. Funding this research would allow this investigator to optimize this compound and prove the drug is effective at stopping HO in FOP cells. This could be a “next generation” treatment option for people with FOP.

Interrogating New Therapeutic Targets for FOP

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Principal Investigator: Ed Hsiao, M.D. and Pam Yelick, Ph.D.
Institution: University of California, San Francisco and Tufts University, United States
Award Amount:  $75,431
Funded in partnership with FOP Australia and FOP Friends®

Project Description: Dr. Hsiao has identified genetic variations in 4 FOP patients exhibiting unusually “mild” FOP disease progression. This research will validate if the same genetic variations are also observed in other less severe FOP patients. The identified human genetic variations will then be “placed” in Dr. Yelick’s FOP zebrafish to assess how these genetic changes impact FOP progression. Ultimately, this research would help the research community better understand why some patients have less severe FOP, and could potentially identify new and effective targets to treat people with FOP.

Modes of Treating FOP with Clinically Relevant ALK2 Inhibitory Compound

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Principal Investigator: Daniel S. Perrien, PhD
Institution: Vanderbilt University Medical Center, United States
Award Amount: $50,000
Funded by Joshua's Future of Promises

Project Description: The mutated ACVR1/ALK2 receptor is the direct cause of heterotopic bone formation in FOP. This research uses a highly specific ALK2 inhibitor that has been developed at Vanderbilt University and licensed to a pharmaceutical company for further drug development. This aim of this research study is to define the stages of heterotopic ossification (HO) formation at which the ALK2 inhibitors is effective at stopping bone formation. By knowing this information, we will know the point at which a potent therapeutic could reverse the early stages of FOP, before a lesion has progressed to mature bone.

Validation of Novel Muscle Regenerating Prophylaxis for FOP-related Heterotopic Ossification

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Principal Investigator: Yuji Mishina, Ph.D. and Benjamin Levi, M.D.
Institution: University of Michigan School of Dentistry and University of Michigan, United States
Award Amount:  $52,208
Funded in partnership with FOP Friends®

Project Description: Drs. Mishina and Levi will be investigating the therapeutic approach of inhibiting a signaling enzyme called TAK1 (Transforming growth factor beta-Activating Kinase 1) and the ability of this inhibitor to prevent spontaneous heterotopic ossification (HO) in a mouse model. The role of TAK1 in early cartilage formation makes it a compelling target for HO prevention. The research will further look at whether TAK1 could also play a role in stimulating muscle regeneration following surgery. The results from this research will inform us whether TAK1 has a role as a future therapeutic that could be used in FOP to both prevent HO and to stimulate muscle regeneration following surgery.

Previous Competitive Research Grant Awardees

2016 Grants

2015 Grants

Competitive Research Grant Scientific Advisory Board

Applications are reviewed by a Scientific Advisory Board that is free of conflict of interest and has relevant and appropriate expertise related to FOP to evaluate proposals.

The IFOPA Scientific Advisory Board includes:

Vicki Rosen, PhD, Chair
Department of Developmental Biology
Harvard School of Dental Medicine

Karen Lyons, PhD
Department of Molecular, Cell and Developmental Biology
UCLA/ Orthopaedic Hospital Department of Orthopaedic Surgery

Ernestina Schipani, MD, PhD
Department of Orthopaedic Surgery
University of Michigan

Michael Whyte, MD
Division of Bone & Mineral Diseases
Washington University School of Medicine

Michael Zasloff, MD, PhD
Department of Surgery Georgetown
University Medical Center

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