Funding Opportunities

ifopa_ResearchGrant_.jpgIFOPA ACT (Accelerating Cures and Treatments) for FOP Grant Program

About the ACT for FOP Grant Program

The IFOPA offers the ACT (Accelerating Cures and Treatments) for FOP grant program to help enable the development of safe and transformative therapies for FOP. The research grant program provides, through a competitive application process, funding to scientists conducting research on fibrodysplasia ossificans progressiva (FOP).

Research Focus

Research grants should focus on the discovery and advancement of therapeutic approaches to FOP, including:

  • Potential new therapies that either provide a novel approach to treating FOP or have convincing animal data to warrant further research;
  • Combination treatments that may provide better efficacy, allow for more persistent treatment, or to allow treatment for the pediatric population;
  • Repurposed drugs that already have a known safety profile and could be a treatment option;
  • Preclinical research that investigates a drug’s effectiveness post-resection of heterotopic bone;
  • Research that further elucidates the mechanisms for FOP muscle and regeneration as well as tendon and ligament repair.

Mechanism of Support

The program awards research grants for a minimum of $25,000 and a maximum of $100,000 for one year. Approximately $100,000 is available for funding in 2018, allowing for either multiple grants of less than $100,000 or a single grant for the full amount. Researchers may receive a second year of funding based on their progress and milestones achieved in the first year and the availability of continued funding.

Applications that are scored favorably but not funded during the initial awards cycle may be funded as additional money becomes available.

Proposals involving meaningful collaboration among investigators with complementary capabilities are encouraged. Awards can be split among investigators’ institutions as needed.

Grant funds may not be used for indirect or overhead costs.

For more information about the ACT for FOP grant program, including information on the evaluation process and criteria, please see the Grant Program Application Guidelines

Eligibility

FOP researchers with a doctoral degree (MD, PhD or equivalent) at any stage of their career in any country are eligible to apply. Applications must be in English. 

Proposal Evaluation Process

All grant applications are blinded with respect to investigator and institution identity for review by the Scientific Advisory Board. The Scientific Advisory Board then rates proposals according to the defined criteria for evaluation and assesses the overall likelihood for the project to make a significant advancement towards for FOP. Once proposals have been fully evaluated on all metrics except for investigator capabilities, the identity of the applicants is unblinded to allow for discussion of investigator and institutional capabilities. The Scientific Advisory Board then develops a recommendation to the IFOPA for funding recipients and amounts.

The IFOPA Research Committee is convened to review the recommendations of the Scientific Advisory Board and to develop a proposal for approval by the IFOPA Board of Directors.

Applications that are scored favorably but not funded during the initial awards cycle may be funded as additional money becomes available.

The Scientific Advisory Board does not provide a written evaluation back to the applicants. 

2018 Application Schedule

May 7, 2018: Announcement of program

July 6, 2018: Deadline for proposals

October 15, 2018: Anticipated award announcement

December 1, 2018: Funding available

How to Apply

Please consult and follow these application materials and instructions:

Grant Program Application Guidelines

Grant Program Terms and Conditions

Complete applications should be submitted in a single PDF file to this email address: grants@ifopa.org.

Scientific Advisory Board

Applications are reviewed by a Scientific Advisory Board that is free of conflict of interest and has relevant and appropriate expertise related to FOP to evaluate proposals.

The IFOPA Scientific Advisory Board includes:

Vicki Rosen, PhD, Chair
Department of Developmental Biology
Harvard School of Dental Medicine
https://hsdm.harvard.edu/people/vicki-rosen

Karen Lyons, PhD
Department of Molecular, Cell and Developmental Biology
UCLA/ Orthopaedic Hospital Department of Orthopaedic Surgery
https://www.mcdb.ucla.edu/Research/Lyons/Lab_members.html

Ernestina Schipani, MD, PhD
Department of Orthopaedic Surgery
University of Michigan
http://medicine.umich.edu/dept/orthopaedic-surgery/ernestina-schipani-md-phd  

Michael Whyte, MD
Division of Bone & Mineral Diseases
Washington University School of Medicine
http://wuphysicians.wustl.edu/physician2.aspx?PhysNum=595

Michael Zasloff, MD, PhD
Department of Surgery
Georgetown University Medical Center
http://explore.georgetown.edu/people/maz5/

Previous ACT (Accelerating Cures and Treatments) for FOP Grant Awardees

2017 Grants

2016 Grants

2015 Grants

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