Basic Science

[listed by category in reverse chronological order]

1. 2013 UCSF / Hsiao lab’s paper on iPS cells
Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M1, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J, Hsiao EC. Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation. Orphanet J Rare Dis. 2013 Dec 9;8:190.

2. 2013 Harvard / Yu lab’s paper on the type II receptor
Bagarova J, Vonner AJ, Armstrong KA, Börgermann J, Lai CS, Deng DY, Beppu H, Alfano I, Filippakopoulos P, Morrell NW, Bullock AN, Knaus P, Mishina Y, Yu PB. Constitutively active ALK2 receptor mutants require type II receptor cooperation. Mol Cell Biol. 2013 Jun;33(12):2413-24.

3. 2012 U Conn / Goldhamer lab’s paper on cells of origin
Wosczyna M, Biswas A, Cogswell C, Goldhamer D. Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification. J Bone Miner Res. 2012 May ; 27(5): 1004–1017.

4. 2012 Oxford / Bullock lab’s paper on the ALK2 crystal structure
Chaikuad A, Alfano I, Kerr G, Sanvitale CE, Boergermann JH, Triffitt JT, Von Delft F, Knapp S, Knaus P, Bullock AN. 2012. Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva Journal of Biological Chemistry, 287 (44), pp. 36990-36998.

5. 2010 Harvard / Medici paper on cells of origin
Medici D, Shore EM, Loune VY, Kaplan FS, Kalluri R, Olsen BR. Conversion of vascular endothelial cells into multipotent stem-like cells. Nature Medicine. 2010 (16; 12):1400-08 Click here for abstract link.

6. 2010 Leiden / ten Dijke lab’s paper on ALK2 function
Dinther M, Visser N, Gorter DJ, Doorn J, Goumans M, Boer J, ten Dijke P. ALK2 R206H Mutation Linked to Fibrodysplasia Ossificans Progressiva Confers Constitutive Activity to the BMP Type I Receptor and Sensitizes Mesenchymal Cells to BMP-Induced Osteoblast Differentiation and Bone Formation. Journal of Bone and Mineral Research. 2010 (25): No. 6.pp 1208–1215.

7. 2006 U Penn / Shore lab’s paper on the gene discovery
Shore EM, Xu M, Feldman GJ, Fenstermacher DA, Cho TJ, Choi IH, Connor JM, Delai P, Glaser DL, LeMerrer M, Morhart R, Rogers JG, Smith R, Triffitt JT, Urtizberea JA, Zasloff M, Brown MA, Kaplan FS. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva.Nat Genet. 2006 May;38(5):525-7. Click here for abstract link.

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